| SignalR | Signed Sealed Delivered | Signed, Sealed, Delivered I'm Yours |
| Signify | Signs | Signs (שיר) |
| Signs of a Struggle | Signs Of A Struggle | Sigrid Rausing |
| SIGTRAN | Sigue | Sigur ros |
| Sigur Ros | SiH4 | SIJ |
| SIKART | SIL International | SILAC |
| Silence | Silence (סרט) | Silence (שיר של מרשמלו) |
| Silence Between Songs | Silence Is Golden | Silent Hill |
| Silent Night | Silent Sun | Silhouette in Red |
| Silhouette in Red Tour | Silk City | Silk Road |
| Silkway איירליינס | Silo (סדרת ספרים) | Silphidae |
| Silver Convention | Silverlight | Silybum marianum |
| SIM | Sim City | Sim ou Não |
| SIMBAD | SimCity | Simcity |
| SimCity (משחק מחשב, 2013) | SimCity (סדרת משחקים) | Simcity 2 |
| Simcity 2000 | SimilarWeb | Simmer |
| Simmer (שיר של מהליה) | Simmer (שיר של היילי ויליאמס) | Simon & Schuster |
| Simon & Speck | Simon and Schuster | Simon The Sorcerer |
| Simon The Sorcerer 2 | Simple API for XML | Simple Life |
| Simple Mail Transfer Protocol | Simple Man (שיר של לנרד סקינרד) | Simple Minds |
| Simple Network Management Protoco | Simple Network Management Protocol | Simple Plan |
| SimpleTypes | Simply Believe | Simply Deep |
| Simply Streisand | Simply the Best | Simpsons Roasting on an Open Fire |
| Sims | Sims 3 | Simultaneous peripheral operations on-line |
| Simultaneous peripheral operations online | Sin | Sin Contrato |
| Sin Miedo (del Amor y Otros Demonios) | Sin Pijama | SIN R1 |
| Sin(x)/x | Sina | Sinapis |
| Sinatra & Company | Sinatra and Strings | Sinatra and Swingin' Brass |
| Sinatra At The Sands | Sinatra Sings Days of Wine and Roses, Moon River, and Other Academy Award Winners | Sinatra Sings Great Songs from Great Britain |
| Sinatra's Sinatra | Sinatra's Swingin' Session!!! | Sinatra-Basie |
| Sinéad O'Connor | Sinc | Since I Lost You |
| Since I've Been Loving You | Since U Been Gone | Sincerely |
| SINE | Sine from Above | Sing (שיר של אד שירן) |
| Sing (שיר של טראוויס) | Sing a song | Sing Hallelujah (שיר של ד"ר אלבן) |
| Sing It with Me | Sing When You're Winning | Sing, Little Birdie |
| Singapore Airlines | Singet dem Herrn ein neues Lied, רי"ב 190 | Singing the Blues |
| Single ladies | Single Ladies | Single Ladies (Put a Ring on It) |
| Single Malt | Single Page Application | Single Sign On |
| Single Soon | Single Top 100 | Singles |
| Sings a String of Harold Arlen | Sings Days of Wine and Roses, Moon River & Other Academy Award Winners | Singular they |
| Singular: Act II | Singularity | Singularity (תוכנה) |
| Sinh | Sinoatrial node | Sinoceratops |
| Sinopec | Sinornis | Sinraptoridae |
| Sinsirella | SIOE | Siouxsie and the Banshees |
| SIP | Sip It | SipHash |
| Siphonaptera | Sippy Cup | Sir-Tech |
| Sire Records | Siredon mexicanum | Sireenit |
| Siren (סרט, 2016) | Siren Song | Sirenia |
| Sirens | Siri | Sirius |
| Sirius XM | SiRNA | SIS |
| Sistema | Sister | Sister Bliss |
| Sister Golden Hair | Sister Outsider | Sisters of Avalon |
| Sit Still, Look Pretty | Sit Still, Look Pretty (שיר) | Sitagliptin |
| Siteswap | SiteSwap | Sitta |
| Sitta neumayer | Sittidae | Sittin' on Top of the World |
| Sitting on the Edge of the Ocean | Sitting Targets | Sivapithecus |
| SIX | Six Degrees of Inner Turbulence | Six degrees of inner turbulence |
| Six Feet Under | Six Feet Under (פסקול) | Six Feet Under (שיר של סמאש אינטו פיסז) |
| Six Feet Under (שיר של בילי אייליש) | Six Flags | SixDegrees.com |
| Sixpence None the Richer | Sixpence None the Richer (אלבום) | Sixteen |
| Sixteen Going on Seventeen | Sizwe Banzi Is Dead | Sizzla |
| S̈ | SJK | SJP |
| Sjuan | SK Hynix | SK שטורם גראץ |
| SK טלקום | SK טירנה | SK בלזמה |
| Sk8er Boi | SKA | SKA פאמיר דושנבה |
| Skat | Skate | Skateboard |
| Skazi | Skein | Skeletons |
| SketchUp | Skibet skal sejle i nat | Skid Row |
| Skidrow | Skillet | Skin |
| Skin (סרט קצר) | Skin (סרט קצר, 1995) | Skin (סרט קצר, 2018) |
| Skin (שיר של סברינה קרפנטר) | Skin of My Teeth | Skin to skin |
| Skool Luv Affair | Skool Luv Affair Special Addition | Skrew |
| Skrillex | SKS ארנה | Sky |
| Sky City | Sky Fits Heaven | Sky News |
| SKY Perfect JSAT | Sky Shield | Sky Shield (חוסם) |
| Skyclad | SkyDrive | Skyfall (שיר) |
| Skylab | Skylake | Skylight |
| SkyLink | Skynet | Skynet (סדרת לוויינים) |
| Skype | Skyrim | SkyRoads |
| Skyroads | Skyscanner | Skyscraper |
| SkySniper | Skyteam | SkyTeam |
| SkyTrain | Skytrain | Skytrain (בנגקוק) |
| SkyTrain (ונקובר) | SkyTran | Skywald Publications |
| Skywriter | Slack | Slack (תוכנה) |
| Slacktivism | Slade | SLAM |
| SLAM-ER | Slamsex | Slant Magazine |
| SLAPP | Slashdot | Slate |
| Slate (magazine) | Slaughterhouse | Slaughterhouse (להקה) |
| Slave of Time | Slave Of Time | Slaves and Masters |
| Slavestate | Slavs! | Slay-Z |
| Slayer | Släpp alla sorger | Sleater-Kinney |
| Sledgehammer | Sledgehammer (שיר של פיפת' הרמוני) | Sledgehammer (שיר של פיטר גבריאל) |
| Sledgehammer (שיר של ריהאנה) | Sledgehammer Games | Sleep (פקודה) |
| Sleep (להקה) | Sleep at Night | Sleeper hit |
| Sleeping Awake | Sleeping Dogs | Sleeping dogs |
| Sleeping Satellite | Sleeping with the Past | Slender |
| Slender: The Eight Pages | SLF4J | SLI |
| Slicker Than Your Average | Slide | Slide Away |
| SlideShare | Slime & B | Slime Language |
| Slime Language 2 | Slime layer | Slime You Out |
